Macro Histone Variants: Emerging Rheostats of Gastrointestinal Cancers
نویسندگان
چکیده
منابع مشابه
Overview of Gastrointestinal Cancers
Cancers of the gastrointestinal (GI) tract include those of the esophagus, stomach, colon, rectum, and anus. Risk factors, incidence, prevalence, and prognosis vary for each site. Many of the risk factors are modifiable, and in a significant number of cases, the cancers are preventable with proper screening and curable when detected and treated at an early stage. Esophageal cancer is a treatabl...
متن کاملImmunotherapy in Gastrointestinal Cancers
Gastrointestinal cancers represent a major public health problem worldwide. Immunotherapeutic strategies are currently under investigation in this setting and preliminary results of ongoing trials adopting checkpoint inhibitors are striking. Indeed, although a poor immunogenicity for GI has been reported, a strong biological rationale supports the development of immunotherapy in this field. The...
متن کاملHistone variants and epigenetics.
Histones package and compact DNA by assembling into nucleosome core particles. Most histones are synthesized at S phase for rapid deposition behind replication forks. In addition, the replacement of histones deposited during S phase by variants that can be deposited independently of replication provide the most fundamental level of chromatin differentiation. Alternative mechanisms for depositin...
متن کاملHistone variants: deviants?
Histones are a major component of chromatin, the protein-DNA complex fundamental to genome packaging, function, and regulation. A fraction of histones are nonallelic variants that have specific expression, localization, and species-distribution patterns. Here we discuss recent progress in understanding how histone variants lead to changes in chromatin structure and dynamics to carry out specifi...
متن کاملCirculating microRNAs: emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers.
To identify novel non-invasive biomarkers for improved detection, risk assessment and prognostic evaluation of cancer, expression profiles of circulating microRNAs are currently under evaluation. Circulating microRNAs are highly promising candidates in this context, as they present some key characteristics for cancer biomarkers: they are tissue-specific with reproducible expression and consiste...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancers
سال: 2019
ISSN: 2072-6694
DOI: 10.3390/cancers11050676